Prepared by:
Hanzala Masood (G14)
Compiled by:
Rukhsar Uns (G14)
Reference Books:
- Lippincott Illustrated Reviews: Biochemistry 7th Edition (Chapter numbers are mentioned according to this edition)
- Satyanarayana Biochemistry 4th Edition
NUCLEOTIDE METABOLISM
Chapter No. 22 from Lippincott
B-001:
- Structure (just give a read)
- Page 292 till Lesch Nyhan Syndrome Purine synthesis (fig 22.6, 22.7, 22.8, 22.9, 22.10 v imp)
- Page 298- 301 Purine Degradation (fig 22.14, 22.15)
B-002:
- Page 302 – end of this chapter
- Pyrimidine synthesis and degradation (22.21, 22.22, 22.23)
B-003:
- Fig 22.8
B-004:
- Regulation of purine and pyrimidine synthesis on page 392 and 398-399 of Satya chap 17
B-005:
- Lesch Nyhan Syndrome (page 296)
- Gout (page 299)
- ADA/ SCID (page 299)
B-006:
- Fig 22.1 and theory on page 302
- Diff of CPS I / CPS II fig 22.20
B-007:
- Synthetic analogs page 73, chap 5 Satya
- PABA analogs/ Mycophenolic acid – fig22.7, 22.8
B-008:
- Role of Ribonucleoside Reductase and its role in Nucleotide metabolism (Hydroxyurea) (v.v imp)
- Completely cover this topic and its clinical example as well as its diagram
ACID BASE BALANCE
B-009/10: (From Satya)
- This Chapter is one of the most important chapter in Block 4. Questions were asked in Scenario, both in our Proff and College Block
- Completely cover this chapter as mentioned below and practice scenario MCQs
- Chap 21 Satya from page 474 (Acid Base Balance) till the end of this chap (along with all the tables) (table 21.4, 21.5, 21.6, 21.7 v imp)
- Metabolic acidosis and alkalosis + Respiratory acidosis and alkalosis, it’s management and causes (very important)
- K+ Regulation imp in acidosis (acute and chronic) and alkalosis
- Diabetic ketoacidosis (important)
- Tetany associated with alkalosis (do it from google)