Medico Guides 2nd Block Physiology Guidelines

Prepared by:

                    Hadia Shakeel (G15)

Compiled by:

                     Hafiz Muhammad Umair Noor (G12)

Recommended Book:

• Guyton and Hall Textbook of Medical Physiology 14^th Edition (Chapter numbers are mentioned according to this edition)

Reference Books:

• Jaypee Essentials of Medical Physiology 9^th Edition

MEMBRANE PHYSIOLOGY

Chapter 5:

MS-P-001:

• Membrane potentials across selectively permeable membrane pg 63  (read for Basic concept + mcqs)

MS-P-002:

• Membrane potential vs Nerst potential
• Nernst potential and it’s basis
• Nernst equation (calculate the Nernst potential  for Na and K by putting values in the equation) v.v.imp

MS-P-003:

• Goldman Equation pg. 64 v.v.imp (use to calculate diffusion potential & resting potential when membrane is permeable to several different ions)
• 4 key points of Goldman Equation
• Normal distribution of Na K Ca and Cl across the cell membrane

MS-P-004:

• Resting membrane potential of neurons pg. 65
• Table 5.1 imp for mcqs
• Fig 5.5
• Origin of RMP & physiological basis i.e factors contributing
• ⁠Hyperkalemia and Hypokalemia( imp)  ( pic is shared in the group)
• ⁠Membrane Stabilizers ( lidocaine, calcium, mexiletine, valproic acid)
• ⁠Inhibition of excitability stabilizers and local anesthetics pg. 76 ( v imp) and their mechanism of action

⁠ MS-P-008:

• Ionic basis of action potential
• Phases of action potential pg. 67 and 68
• Definition of action potential
• Properties of action potential will be covered in the table containing differences between action and Graded potential
• Pics for monophasic action potential and refractory period are shared in the grp.
• Role of Other ions during action potential pg 70 blue box ( v imp + tetany is seq ) role of Ca+ in it
• Rheobase , chronaxie , utilization time ( vimp pic is shared in the group)

MS-P-011:

• Special characteristics of signal transmission in nerve trunks (imp) pg 74
• saltatory conduction and its importance

Chapter 31: (Jaypee)

MS-P-10:

• Graded potential + table 29.1 basis& properties
• Graded vs Action Potential difference
• Compound Action Potential .. basis& properties
• From jaypee chap 29 pg 173 for compound action potential and pg no 174 for graded potential
• For EPSP and IPSP Fig no 137.4 and 137.5

AUTONOMIC NERVOUS SYSTEM

MS-P-007

• ANS is supposed to be covered from Chp 61 pg no 763 to 770…
• Receptors of ans can be covered from receptor tables in block 1 pharma…
• The most imp thing in this chp is the table 61.2…..apko mcqs yahe se ane hain to isko bohat ache se prepare kerna hay
• You can also watch the yt lecture of Dr.asif qureshi for this chp.

NERVE PHYSIOLOGY

Chapter 131:(Jaypee)

MS-P-005:

• Physiological anatomy of neuron
• Complete chapter till functions of neurilemma
• Neuron anatomy
• Myelin sheath, neurilemma
• Process of myelination
• For Axonal transport pic is shared in the grp

Chapter 135: (Jaypee)

MS-P-005(b):

• Complete chapter 
• Neuroglial cells and their roles

Chapter 133: (Jaypee)

MS-P-006:

• Properties of nerve fibers
• Don’t go into the detail of this chapter just cover it superficially
• Focus on basic definitions of the properties of neuron

Chapter 132: (Jaypee)

• Complete chapter
• Nerve fibers classification  table 132.1…..table bohat imp hay ise may say mcqs ayein ga apko

Chapter 137: (Jaypee)

MS-P-011: Synapse

• Fig 137.3
• Functional classification of synapse
• Fig 137.2

Chapter 134: (Jaypee)

MS-P-013:

• Multiple Sclerosis Chp 1 pathology section block 2
• GB syndrome from chp 1 pathology section block 2
• Causes, features and pathophysiology
• Degeneration of neuron (Wallerian Degeneration)  
• Regeneration of neuron

MUSCLE PHYSIOLOGY

Chapter 6:

MS-P-014:

• Physiological anatomy of skeletal muscle
• Sarcomere
• Fig 6.3

MS-P-015:

• ⁠ Characteristics of muscle contraction
• Fig 6.12
• Also do examples Of Isotonic and isometric contraction
• Fast vs slow muscle fibers

MS-P-016:

• Motor unit
• Force summation
• Multiple summation
• Frequency summation and tetanization (imp)
• Treppe
• muscle fatigue
• Remodeling +Blue box

Chapter 7:

MS-P-017:

• Complete Chapter
• Anatomy, generation and conduction of impulse at NMJ
• Generation of endplate potential
• Excitation and contractions coupling v.v.imp.
• Myasthenia Gravis (v.imp )
• NMJ enhancer and inhibitors

Chapter 8:

MS-P-018:

• Types of Smooth Muscle
• Physiological basis Of Smooth Muscle contraction
• Smooth muscle contraction without Action Potential
• Hormones causing contractions without Action Potential
• Latch mechanism and importance
• Stress Relaxation
• Regulation By Calcium
• Nervous and hormonal Control (Complete till end)
• Comparison between skeletal and smooth muscle contraction