Medico Guides 2nd Block Physiology Guidelines

by

Prepared by:

                     Hassan e Muhammad (G14)

Compiled by:

                     Hafiz Muhammad Umair Noor (G12)

Recommended Book:

  • Guyton and Hall Textbook of Medical Physiology 14th Edition (Chapter numbers are mentioned according to this edition)

Reference Books:

  • Jaypee Essentials of Medical Physiology 6th Edition

MEMBRANE PHYSIOLOGY

Chapter 5:

MS-P-001:

  • Membrane potentials across selectively permeable membrane pg 63  (read for Basic concept + mcqs)

MS-P-002:

  • ⁠Normal distribution of Ca Cl Na and K across membrane from fig 4.1
  • Membrane potential vs Nerst potential
  • Nernst potential and it’s basis
  • Nernst equation (calculate the nernst potential  for Na and K by putting values in the equation)

MS-P-003:

  • Goldman Equation pg 64 imp(use to calculate diffusion potential & resting potential when membrane is permeable to several different ions)

MS-P-004:

  • Resting membrane potential of neurons pg 65
  • Table 5.1 (mcqs)
  • Fig 5.5
  • Origin of RMP (seq)  & physiological basis i.e factors contributing
  • ⁠Hyperkalemia and Hypokalemia( imp)  ( pic is shared in the group)
  • ⁠Membrane Stabilizers ( lidocaine, calcium, mexiletine, valproic acid)
  • ⁠Inhibition of excitability stabilizers and local anesthetics pg 76 ( v imp) and their mechanism of action

MS-P-007:

  • Neuron action potential pg 67 (definition+ all stages)
  • Fig 5.6 imp ( also do it from the pic shared in the group )
  • Voltage gated Na and K channels
  • Na channels can be blocked by tetrodotoxin when applied outside the cell membrane (mcq)
  • K channels can be blocked by tetraethylammonium ion when applied to interior of nerve fibre (mcq)
  • Initiation of action potential pg 71( read)
  • Propagation of action potential (read)
  • All or nothing principle pg 72 (imp)
  • Re establishing Na and K ionic gradients after action potential pg 72 (imp)
  • Properties of action potential (pic is shared in the group)
  • Monophasic action potential (pic is  shared in the group)
  • Refractory period ( pic is shared in the group) relative v/s absolute

⁠ MS-P-008:

  • Role of Other ions during action potential pg 70 blue box ( v imp + tetany is seq ) role of Ca+ in it
  • Rheobase , chronaxie , utilization time ( vimp pic is shared in the group)

MS-P-011:

  • Special characteristics of signal transmission in nerve trunks (imp) pg 74
  • saltatory conduction and its importance

Chapter 31: (Jaypee)

MS-P-009(a):

  • Graded potential + table 31.1 basis& properties
  • Graded vs Action Potential difference
  • Compound Action Potential .. basis& properties

NERVE PHYSIOLOGY

Chapter 134:(Jaypee)

MS-P-005(a):

  • Complete chapter till functionsof neurilemma
  • Neuron anatomy
  • Neuron classification
  • Myelin sheath, neurilemma

Chapter 138: (Jaypee)

MS-P-005(b):

  • Complete chapter 
  • Neuroglial cells and their roles
  • Myelination process
  • Axonal transport ( pic is shared in the group)

Chapter 135: (Jaypee)

MS-P-006:

  • Complete chapter
  • Nerve fibers classification  table 135.1

Chapter 140: (Jaypee)

MS-P-009(b): Synapse

  • Fig 140.4
  • Fig 140.5

MS-P-010:

  • Functional classification of synapse
  • Fig 140.2 +140.3

Chapter 137: (Jaypee)

MS-P-012:

  • Multiple Sclerosis
  • GB syndrome (google)
  • Causes, features and pathophysiology
  • Degeneration of neuron two types
  • Regeneration of neuron

MUSCLE PHYSIOLOGY

Chapter 6:

MS-P-013:

  • Physiological anatomy of skeltal muscle
  • Sarcomere
  • Fig 6.3
  • Jaypee Table 28.1 (Diference)

MS-P-014:

  • ⁠ Charcteristics of muscle contraction
  • Fig 6.12
  • Also do examples Of Isotonic and isometric contraction
  • Fast vs slow muscle fibres

MS-P-015:

  • Motor unit
  • Force summation
  • Multiple summation
  • Frequency summation and tetanization (imp)
  • Treppe
  • muscle fatigue
  • Remodeling +Blue box

Chapter 7:

MS-P-016:

  • Complete Chapter
  • Anatomy, generation and conduction of impulse at NMJ
  • Generation of endplate potential
  • Excitation and contractions coupling (imp)
  • Myasthenia Gravis (v.imp )
  • NMJ enhancer and inhibitors

Chapter 8:

MS-P-017:

  • Types of Smooth Muscle
  • Physiologivcal basis Of Smooth Muscle contraction
  • Smooth muscle contraction without Action Potential
  • Hormones causing contractions without Action Potential
  • Latch mechanism and importance
  • Stress Relaxation
  • Regulation By Calcium
  • Nervous and hormonal Control (Complete till end)
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