Prepared by:
Warda Mehmood (G15)
Compiled by:
Hafiz Muhammad Umair Noor (G12)
Recommended Book:
- Guyton and Hall Textbook of Medical Physiology 14th Edition (Chapter numbers are mentioned according to this edition)
- NIMS Blood Physiology (Only for Topic of Blood)
- Jaypee Essentials of Medical Physiology 6th Edition
BLOOD PHYSIOLOGY
Chapter 33: ( HL-P-001,002)
- Anemia (v.v.v imp)
- Etiological classification from Guyton
- Morphological classification from NIMS (Pic is given here)
- Effect of anemia: Make a flow chart of it. (Pic is given below, also in paragraph of guyton under Heading : Effects of anemia on circulatory system pg 446)
- Polycythemia (Guyton)
- Secondary Polycythemia (Physiological) (For MCQs)
- Polycythemia Vera/ Erythremia (Pathological)
(Do their comparison)
- For effects of Anemia and Polycythemia make flowcharts (imp)
Chapter 35: ( HL-P-007,008,009)
- Immunity (Definition)
- Types of immunity (pic is given below)
- Innate immunity (Definition along with four points)
- Acquired immunity (Definition)
- Difference b/w humoral and cell mediated immunity
- Concept of antigen and epitope
- Pg 460-462, Figure 35.1 for understanding (read for concept and mcqs)
- Antibody formation by plasma cells
- Formation of memory cells enhances antibody response to subsequent antigen exposure (imp)
- Figure 35.3
- Nature of antibodies
- Classes of antibodies
- Mechanism of action of antibodies (direct and complement system) v imp
- Fig 35.6 (imp)
- Antigen presenting cells, major histocompatibility complex proteins (imp)
- Different types of T cells (complete topic till pg 468 along with fig 35.8) imp
- Table 35.1 (types of T helper cells viva question)
- Tolerance of acquired immunity system to body own tissue (Def imp for viva)
- Active and passive immunity (diff v imp)
- Allergy and hypersensitivity (complete) high yield mcqs (v imp)
Chapter 36: (HL-P-010,011,012)
- Page 471-473 give a good read for better understanding
- RH incompatibility (erythroblastosis fetalis) v.imp for viva and mcqs
- Transfusion reactions from mismatched blood types
- Transplantation of tissues and organs (complete topic till page 476)
- Transfusion reactions due to ABO incompatibility (jaypee chap 21 page 141-142 read from there)
- Changes in stored blood (pic is shared in the group)
Chapter 37: (most imp chapter) ( HL-P-003,004,005,006)
- Hemostasis (Def)
- Events in hemostasis (imp seq)
- characteristics of platelets
- Vascular Constriction (Complete)
- Formation of platelet plug(complete)
- TABLE 37.1(Complete) , pneumonic to learn it : Foolish People Try Climbing Long Slopes After Christmas Some People Have Fallen
- Mechanism of blood coagulation (Complete)
- Fig 37.3 (imp)
- Extrinsic and Intrinsic pathway (v.v.imp)
difference btw them (along with figures)
- Anticoagulants for clinical use
- Intravascular anticoagulants
- Role of Calcium
- Blood coagulation test
- Conditions that cause excessive bleeding (Hemophilia, Thrombocytopenia, Vitamin K) (vimp)
- (Must do this chapter from Guyton)
Points To Remember: (viva /mcqs)
- Stimulus for Intrinsic pathway:
- Internal damage
- Glass contact
- Blood trauma
- Test tube coagulation
- Stimulus for Extrinsic pathway:
- Surgery
- Inflammation
- Shave cut
- Knife cut
- Vitamin K dependent CF -> 2,7,9,10
- Bleeding Time increase in >>> Thrombocytopenia
- Clotting time increase in. >>> Hemophilia
- Purpura (Tendency of spontaneous hemorrhage beneath skin, internal organs.
Types of Purpura:
- Thrombocytopenic purpura
- Multiple subcutaneous hemorrhage
- Poor constriction of blood vessel
- Dec platelet count
- Clot retraction deficiency
- Non-Thrombocytopenia
- Functionally defective platelet (Thrombasthenia)
- Platelet count normal
- Due to allergy
- Infection
- Tips For proff and college block preparation: I suggest you to stick to your recommended book (Guyton) rather than going for short books, as guyton covers all your proff and block mcqs if you have prepared from it. Also for doing MCQ’s practice , you can do it from Chapter 1 past MCQ’s.
- Recommended youtube channel: Medical Gateway