Medico Guides 5th Block Embryology Guidelines

Prepared by:

                 Hadia Imtiaz (G13)   

Compiled by:

                  Hafiz Muhammad Umair Noor (G12)

UHS 5th Block

  (Module No 08)

  • Langman Medical Emryology 14th Edition

Note:

  • Only Langman is enough. Make flowcharts of imp topics and MCQs are often asked e.g which part develops from which embryonic tissue

EnR-A-026:

  • Complete thyroid development (initial development and descent + types of cells)
  • Thyroglossal duct/cyst is very imp

EnR-A-027:

  • Written in 3rd and 4th pharyngeal pouches (understand and try to write it in your own words as it’s scattered here)
  • Histogenesis

EnR-A-028:

  • Simple clinical, especially remembering the most common ectopic/aberrant location.

EnR-A-032:

  • The concept about indifferent gonads and SRY gene is imp, rest is just read
  • Development of testis (read)
  • Descent of testis(imp)

EnR-A-033:

  • Clinical of undescended testis (cryptorchidism) (v imp)

EnR-A-034:

  • It covers complete genital system development.
  • Give a read to the whole topic from the book (for mcqs and concept) then do it from the 2nd year embryo notes
  • All clinicals are important so do all of them, nothing to skip here (uterus clinicals are very imp)

EnR-A-029:

  • Pituitary development is written in the forebrain section
  • High Yield things are sources and types of tissues (also Table 17-1)
  • Clinical [craniopharyngiomas (imp)]

EnR-A-030 & 031:

  • Development of suprarenal glands+clinical (not much imp, read it)

UHS 5th Block

(Module No 09)

HNSS-A-035:

  • Study pharyngeal apparatus and its components table 17.1 (vvv imp)
  • Make notes of all the derivatives of pharyngeal pouches, arches, membranes & grooves (as all these often get confused and asked about)

HNSS-A-036:

  • If you study thoroughly, all these will be covered in the upper section, these are just sub-divisions of it.

HNSS-A-037:

  • All clinicals here are important

HNSS-A-038:

  • The thyroid part is covered in module 8.
  • Do tongue development and its clinicals.

HNSS-A-039:

  • Face and nasolacrimal duct development (especially facial prominences and their derivatives and their clinicals)

HNSS-A-040:

  • Simple read to paranasal sinuses (not much imp)

HNSS-A-041:

  • Development of lip & palate and their clinicals of cleft lip & palate are very imp

HNSS-A-042:

  • Do eye and inner ear development (not imp) from Sharjeel and all their clinicals from books. And clinical from Langman

Medico Guides 5th Block (Module No 09) Physiology Guidelines

Prepared by:

                   Usman Qaisar (G13)

Compiled by:

                   Hafiz Muhammad Umair Noor (G12)

Recommended Book:

  • Guyton and Hall Textbook of Medical Physiology 14th Edition (Chapter numbers are mentioned according to this edition)

SPECIAL SENSES

HNSS-P-001:

  • Optics of eye(read)
  • Emmetropia (imp)
  • Hyperopia comp
  • Myopia comp 
  • Astigmatism (imp)
  • Give read to correction of optical abnormalities with contact lenses

HNSS-P-002:

  • Treatment of refractive errors
  • Definition of visual acuity

HNSS-P-003:

  • Fluid system concept (imp)
  • Outflow of aqueous humor (very imp) (proff mcq)
  • Intraocular pressure normal value (imp) + it’s regulation

HNSS-P-004:

  • Glaucoma (open + closed angle ) imp

HNSS-P-005:

  • Retina layers(vvv imp seq + mcq) with fig 51.1
  • Fovea of retina (imp) + optic disc
  • Rods and cones structure + fig 51.3 (vvv imp)
  • Pigment layers of retina (melanin + vitamin A) imp
  • Retinal blood supply + retinal detachment (imp)

HNSS-P-006:

  • Visual cycle (imp) + fig 51.5 + activated rhodopsin (imp seq)
  • Role of vitamin A + night blindness (scenario based seq)
  • Excitation of rods + fig51.6 + fig 51.7 (vvv imp)
  • Do make a concept of hyperpolarization + photo transduction (imp for proff)
  • Read to excitation cascade

HNSS-P-007:

  • Light and Dark adaptation (vvv imp proff seq)
  • OOtherMechanisms

HNSS-P-008:

  • Read to color vision + do definitions of protonope + deuteranope + tritonope (for mcq)
  • Neural functional layer of retina (imp cells)
  • Visual pathway + fig 51.12 (imp)
  • Important neurotransmitters
  • Make a concept of how signals transmitted through electronic conduction not by action potential (imp viva question)
  • Lateral inhibition (imp for mcq)
  • Types of bipolar cells (imp)
  • Amacrine cells (imp for mcqs)

HNSS-P-009:

  • Visvual pathway (vvvvv imp for proff + sendup) + visual fibers going to 5 older areas of brain
  • Function of lateral geniculate nucleus (imp) + it’s layers + gating system
  • Primary + secondary visvual Cortex fig 52.2 + fig 52.3 (mcq)
  • Effect of removing primary visual cortex (imp viva)
  • Abnormalities of visual pathway (chart will share in below shared pictures) (vvv imp mcq + seq)

HNSS-P-010:

  • Physiology blind spot (imp mcq + seq)
  • Scotoma

HNSS-P-011:

  • Abnormalities of visual field

HNSS-P-012:

  • Macular control of eye moment (imp)
  • Neural pathway

HNSS-P-013:

  • Strabismus (imp) + fig 52.10

HNSS-P-014:

  • Mechanism of accomodation
  • Accomodations for far and near (imp)
  • Parasympathetic control of accomodation
  • Presbyopia (imp)
  • Control of accomodation (Chp 52)

HNSS-P-015:

  • Pupillary light reflex (imp for seq)
  • Pupillary reflexes in CNS diseases (Edinger Westphal nucleus) + (Argyll Robertson pupli) (imp)
  • Horner syndrome
  • Differential diagnosis of anisocoria (picture share below)

HNSS-P-016:

  • 53.1 (imp) + do read a detail for better understanding
  • Impedence matching (vvvv imp seq)
  • Attenuation reflex (vvv imp seq scenario based)
  • Otomycosis
  • Impacted ear wax

HNSS-P-017:

  • Read of functional anatomy of cochlea
  • Fig 52.3 (imp for mcqs)
  • Basilar membrane concept
  • Transmission of sound waves in cochlea + vibration patterns (imp seq)

HNSS-P-018:

  • Function of organ of corti fig 53.6
  • Excitation of hair cells (imp)
  • Transmission of auditory signal + fig 53.7 (imp seq+ mcq)
  • Endocochlear potential (imp)

HNSS-P-019:

  • Normal rage of hearing
  • Place principal (vvvv imp seq)
  • Volley’s principal
  • Determination of loudness (imp seq)

HNSS-P-020:

  • Auditory nervous pathway + fig53.9 (vvv imp seq)
  • Type of deafness (imp seq)

HNSS-P-021:

  • Primary taste sensations (names + how it produce)
  • Taste blindness (imp)
  • Read to taste buds and it’s function
  • Location of taste buds + fig 54.1

HNSS-P-022:

  • Mechanism of stimulation of taste buds (vvv imp)
  • Transmission of taste signals + fig 54.2 ( vvvvv imp for seq)

HNSS-P-023:

  • Definition of aguesia, hypoguesia, hyperguesia, dysgeusia (imp seq+ mcq)

HNSS-P-024:

  • Taste preference and aversion

HNSS-P-025:

  • Sense of smell
  • Olfactory membrane+ fig 54.3 (read)
  • Stimulation of olfactory cells (read )
  • Action potential in olfactory cells (imp)
  • Primary sensation of smell (vvv imp seq)
  • Transmission of smell signals , older and newer olfactory pathways(read)

HNSS-P-026:

  • Rhinitis
  • Difference between viral and allergic rhinitis

Do all these topics from firdous as well for a quick review

Medico Guides 5th Block (Module No 09) Biochemistry Guidelines

Prepared by:

                  Nofal Anjum Khan (G13)   

Compiled by:

                  Hafiz Muhammad Umair Noor (G12)

  • Lippincott Illustrated Reviews: Biochemistry 8th Edition
  • Satyanarayana Biochemistry 6th Edition
  • Harper’s Illustrated Biochemistry 30th Edition

CARBOHYDRATE METABOLISM

(HNSS-B-001a)

  • Read complete chapter but Diseases are most important
  • Read to fructose metabolism + it’s phosphorylation+ fructose 1-P cleavage (fig 12.2) (imp) + it’s kinetics
  • Fig 12.3 (most imp fig for seq + mcq)
  • Enzymes deficent + product accumulate + it’s effect in essential fructosuria and hereditary fructose intolerance (vvvvvv imp seq + mcq)
  • Aldolase B deficiency v.v.v.imp
  • Mannose conversation to fructos-6-P
  • Glucose conversation to fructose via sorbitol (vvvv imp)
  • Fig 12.4 (imp) + sorbitol synthesis
  • Hyperglycemia and sorbitol mechanism (vvvv imp) and how it causes cataract and peripheral neuropathy (imp)
  • Do galactose n fructose metabolism
  • Fig 12.5 v.imp

VITAMINS

(HNSS-B-001b)

  • Vitamin A (vvv imp)
  • Structure
  • Absorption and transport + release from liver with fig 28.19 (imp)
  • Fig 28.19 (vvvvvv imp)
  • Functions (visual cycle) (imp)
  • Deficiency (nyctoplasia + skin conditions) (imp)
  • Vitamin A toxicity
  • Should clearly describe the physiological and therapeutic function of Vit A (Fig28.21 imp)

Medico Guides 5th Block (Module No 08) Gross Anatomy Guidelines

Prepared by:

                  Hadia Imtiaz (G13)                    

Compiled by:

                   Hafiz Muhammad Umair Noor (G12)

Reference Books:

  • Snell’s Clinical Anatomy
  • Cover all topics and clinicals from Snell and if any clinical or topic mentioned in your LOs is not in Snell’s then cover it from KLM or any other book

HEAD AND NECK

  • Thyroid Gland:
    • Gross features (important) (Location, extent, etc)
    • Relations (v imp for viva)
    • Blood supply (vv imp)
  • Parathyroid Gland:
    • Read regardly
  • Clinicals:
    • Thyroidectomy and its manifestations (vv imp)
  • Pituitary Gland: (not much imp)
    • Location
    • Functions
    • Arterial and Venous supply

PELVIS PART 1 AND 2

  • Pelvis:
    • Gross features viva
    • Read true and false pelvis and their content for concepts
    • Difference between Male and Female Pelvis (vv imp)
    • Different types of Pelvis (v imp
    • Sacrum imp for viva only
  • Testis: (this portion is written in abdomen portion of Snell’s)
    • Gross features (coverings of testis v imp)
    • Blood supply (vv imp especially venous drainage)
  • Epididymis:
    • Read
  • Clinicals: vvvimp
    • Cryptorchidism (imp)
    • Varicocele (vv imp)
    • Ectopic testis (imp)
    • Hydrocoele (vv imp)
  • Suprarenal Gland: (this portion is written in abdomen portion)
    • Gross features, Difference between right and left Suprarenal gland’s relations structure and Neurovascular supply (imp)
  • Clinicals:
    • Difference between Addison and Cushing disease (imp)
    • Phaeochromocytoma (imp
  • Urethra:
    • Parts of the male urethra (vv. imp)
  • Clinicals:
    • Uretric colic (imp)
    • Suprapubic cystotomy (imp)
    • Rupture of Bladder (imp)
    • Cystocele (imp)
  • Ovaries:
    • Read Gross features (Position of ovaries)
    • Ligaments are imp
    • Neurovascular supply (v imp)
  • Uterine Tubes:
    • Unimp Do only ns bs
  • Uterus:
    • Gross features Read
    • Neurovascular supply (imp)
    • Lymphatic drainage (v imp)
    • Support of Uterus (vvv imp)
  • Vagina:
    • Gross features unimp(Read)
    • Neurovascular supply (imp)
  • Clinicals:
    • Ovarian cysts (v imp)
    • Chocolate cyst in ovaries (imp)
    • Salpingitis (imp)
    • Tubal ligation and Tubectomy (imp)
    • Read clinicals of Vagina
    • Cystocele (imp)
  • Accessory Male Glands:
    • Vas deference, Seminal vesicles, and Ejaculatory duct (unimp)
  • Prostate: (vvvimp topic)
    • Gross features all (Zones and lobes vv imp)
    • Capsule (True and False imp)
    • Neurovascular supply (imp)
    • Age changes read for Mcqs
  • Vessels Of Pelvis:
    • Internal Iliac artery complete (v imp)
    • Internal Iliac vein (unimp)
    • Lymph nodes of Pelvis (v imp)
  • Nerves Of Pelvis:
    • Lumbosacral and Coccygeal plexus (v.imp) (also practice how to draw it)
    • Pelvic autonomic nerves skip them
  • Pelvic Fascia (v.imp)
  • Pelvic Muscles:
    • Pelvic floor/Diaphragm i.e muscles of Levator ani (vv  imp) (must do) do muscle table only
  • Joints Of Pelvis:
    • Sacroiliac joint complete (v imp)
    • Other joints (just read)

Chapter 8: (Perineum)

  • Pelvic diaphragm
  • Content of anal triangle imp
  • Skip anal canal till defecation
  • Ischioanal fossa +content imp
  • Urogenital triangle imp
  • Superficial fascia
  • Urogenital diaphragm
  • Perineal body imp
  • Do superficial and deep perineal pouches +content tables from b.d well written their also do perennial membrane from their
  • Penis and scrotum blood supply n.s skip rest
  • Skip reat chp
  • Do related clinicals

Medico Guides 5th Block (Module No 08) Physiology Guidelines

Prepared by:

                   Alisha Athar (G13)                  

Compiled by:

                   Hafiz Muhammad Umair Noor (G12)

Recommended Book:

  • Guyton and Hall Textbook of Medical Physiology 14th Edition (Chapter numbers are mentioned according to this edition)

ENDOCRINOLOGY

  • Endocrinology by Dr Ameena PDF has been shared, it’s better to do it from Guyton and PDF

EnR-P-001(a):

  • Chemical messengers
  • Chemical structure and synthesis of hormones
  • Table 75.1
  • Clearance of hormones
  • Mechanism of action of hormones
  • Receptors and activation
  • Down regulation of receptors
  • Fig # 75.4
  • Enzyme-linked hormone receptor
  • Table 75.2
  • Fig 75.5
  • Intracellular hormone receptors
  • Fig 75.6
  • Table 75.3
  • Table 75.4
  • Fig 75.7
  • Fig 75.8
  • Ca calmodulin system

EnR-P-001(b):

  • Names of anterior and posterior pituitary harmones
  • Cell types and hormones of pituitary with table 76.1
  • Fig 76.4
  • Table 76.2
  • Hypothalamic releasing and inhibitory harmones
  • Growth Hormone (imp)
  • Physiological functions
  • Metabolic effects (whole v imp read flowcharts from pdf)
  • Fig 76.6
  • Table 76.3( v imp)
  • Effect of GH on proteins
  • Effect of GH on Fats
  • Ketogenic effect v imp
  • Effect of GH on carbohydrates vvimp
  • Necessity of insulin and carbohydrates…
  • Effect of GH on cartilage and bones
  • Somatomedins (vvvvvvv imp)
  • Difference between GH and Somatomedins (from pdf shared)
  • Regulation of growth hormone secretion (read for concept. you can also read it from pdf)
  • Abnormalities of Growth Harmone secretion (complete blue boxes) v imp
  • Panhypopituitarism with causes and treatment
  • Sheehan syndrome from Google (imp)
  • Panhypopituitarism in childhood and dwarfism
  • Difference between Loran dwarfs and African pygmies
  • Gigantism (before adolescence)
  • Acromegaly (after adolescence) also do it from pdf
  • Posterior pituitary gland (give a read from pdf)
  • Physiological function of ADH
  • Fig 76.10
  • Vasoconstrictor effects of ADH
  • Oxytocin functions

EnR-P-002:

  • Synthesis and secretion of thyroid harmones
  • Steps for synthesis of thyroxine (all steps imp)
  • Fig 77.2 (vimp)
  • Difference between T3 and T4 (from pdf shared)
  • Transport of thyroxine
  • Physiological functions of thyroid hormones with fig 77.5 complete till page 948
  • Regulation of thyroid hormones (Imp)
  • TSH
  • Fig 77.7
  • Antithyroid substances all (Imp)
  • Diseases of thyroid (complete till the end of this chapter)
  • Hyperthyroidism (causes, symptoms, exophthalmos, diagnosis (Imp) treatment)
  • Hypothyroidism (causes, endemic, idiopathic, characteristics) (Imp)
  • Myxedema (Imp)
  • Diagnosis
  • Cretinism (Imp)
  • Difference between Cretinism and dwarfism ( in pdf shared)

EnR-P-003:

  • Names of adrenal hormones
  • Synthesis and Secretions of adrenocortical hormones
  • Mineralocorticoids imp
  • Glucocorticoids imp
  • Fig 78.2 (v v Imp)
  • Plasma bound hormones
  • Adrenocortical hormones are metabolized in liver
  • Functions of Mineralocorticoids (also read from pdf shared)
  • Mineralocorticoid deficiency causes renal NaCl wasting…
  • Apparent Mineralocorticoid Excess Syndrome (AME)
  • Renal and circulatory effects
  • Aldosterone escape imp
  • Excess aldosterone effects
  • Deficiency of aldosterone
  • Fig 78.4
  • Regulation of aldosterone secretion (v imp)
  • Function of glucocorticoids
  • Effects of cortisol on carbs, protein, fats
  • Adrenal diabetes
  • Cortisol prevents inflammation (Imp)
  • Anti inflammatory effects (seq)
  • Fig 78.7
  • Regulation of cortisol secretion
  • Fig 78.8
  • Circadian rhythm of glucocorticoids
  • Synthesis and secretion of ACTH (read for concept)
  • Adrenal androgens (complete till the end of chapter) v imp
  • Difference btw Cushing disease and Cushing syndrome (google)

EnR-P-004:

  • Physiological anatomy of the pancreas
  • Insulin synthesis and synthesis with Fig 79.2
  • Activation by insulin and effects with Fig 79.3
  • Effect of insulin on glucose ( all)
  • Insulin promotes liver storage and use of glucose
  • Glucose released from the liver between meals
  • Lack of insulin effect on the brain
  • Effect of insulin on fat synthesis and storage
  • Insulin deficiency causes lipolysis (Imp)
  • Effect of insulin on protein metabolism
  • Fig 79.7
  • Table 79.1 (v imp)
  • Factors that stimulate insulin secretion
  • Glucagon (complete)
  • Somatostatin in blue box (Imp)
  • Summary of glucose regulation
  • Importance of blood glucose regulation

EnR-P-005:

  • Diabetes mellitus (give a thorough read to whole topic as it is v important )
  • DM type 1 (cause dehydration, polyuria, metabolic acidosis, polyphagia… explanation given in pdf shared)
  • Treatment of DM type 1 (Imp)
  • Type 2DM (causes
  • Metabolic syndrome
  • Table 79.2
  • Table 79.3
  • Treatment of type 2DM
  • Insulinoma (Imp)
  • Hypoglycemia

Note: Do this chapter from Firdous. Extra topics to be done from Guyton are mentioned below.

EnR-P-006, 007

  • Osteolysis (rapid phase of Ca and phosphate mobilization)
  • Slow phase of bone resorption (activation of osteoclasts)
  • Fig 80.6 (read)
  • Fig 80.8( imp)
  • Fig 80.14
  • Summary of effects of parathyroid (Imp)
  • Do all clinicals from blue boxes (complete)
  • Difference btw rickets and tetany

EnR-P-008:

  • Adrenal medullary harmones and pheochromocytoma ( from google or lec slides)

REPRODUCTION AND LACTATION

Important Note:

  • It’s better to do it from Firdous physiology with Guyton
  • The whole topic of reproduction and lactation from Firdous
  • The topics which you’ve to do from Guyton are mentioned below.

(EnR-P-009 to 015)

  • Fig 81.3(total 74 days )
  • Capacitation( imp)
  • Acrosome reaction (imp)
  • Why does only one sperm enter the oocyte?
  • Estrogen production in male ( written in blue box) read
  • Basic intracellular mechanism of action of testosterone (read)
  • Fig 81.10 (read)
  • Fig 82.3
  • Fig 82.4 (concept)
  • Fig 82.6(imp)
  • Fig 82.7
  • Fig 82.8 imp
  • Fig 82.9 82.11 read
  • Menopause
  • Double Bohr effect (read once for concept) written in diffusion of oxygen through placenta
  • Response of mother’s body during pregnancy (in blue box)
  • Parturition
  • Oxytocin causes contraction of the uterus
  • Onset of labor (+ve feedback)
  • Fig 83.10

Medico Guides 5th Block (Module No 08) Biochemistry Guidelines

Prepared by:

                  Aneesa Asif (G13)

                  Nofal Anjum Khan (G13)

Compiled by:

                  Hafiz Muhammad Umair Noor (G12)

  • Lippincott Illustrated Reviews: Biochemistry 8th Edition (Chapter numbers are mentioned according to this edition)
  • Satyanarayana Biochemistry 6th Edition
  • Harper’s Illustrated Biochemistry 30th Edition
  • Mark’s Biochemistry 6th Edition
  • Lehninger Principles of Biochemistry 7th Edition
  • Lippincott Illustrated Reviews: Cell and Molecular Biology 2nd Edition

ENDOCRINE BIOCHEMISTRY

(EnR-B-001)

  • Do this from Guyton chp 75. By doing complete chapter u will cover these LOs.
  • Tables of chap 75 are v.v.v.imp

(EnR-B-002)

  • Do this from the pics/pdf shared

(EnR-B-003)

  • Do this from Satya chapter 19
  • You can also do it from Harper chapter 42 (pics are shared)

(EnR-B-004a)

  • Do this from pdf/pics shared

(EnR-B-004b)

  • Do this from Lippincott chapter 23
  • Insulin synthesis v.v.v.imp
  • Can also do from Guyton chapter 79

(EnR-B-004c)

  • Do this from Lippincott chapter 21(III-A) page no 317 to 319

(EnR-B-004d & 007)

  • Do these from Guyton chapter 76, 77 & 78
  • U can also do cortisol and other steroid hormones from Lippincott chapter 18 (VII) pg no 262 to 266

(EnR-B-005)

  • This is a general LO. It will be covered by doing other LOs.

(EnR-B-006)

  • Do this from Guyton chapter 78
  • Pro-opiomelanocortin gene topic complete

(EnR-B-008)

  • Do these from pics/pdf shared

GENETICS

(EnR-B-009 to 015)

  • Do these from the pics/pdfs shared

(EnR-B-016 to 017)

  • The topic of Karyotypes is not given in the book. Do it from pics shared.
  • As far as mutations are concerned, some of them are given in Lippincott chapter 32(II-C pg 498 & 499). Rest will be shared as pics.

(EnR-B-018 to 021)

  • No need to do the the structure of DNA as it is not the part of ur syllabus
  • Start from (III-Steps in ….) pg no 462 to 475
  • Although whole chapter is imp but the most important topics are below
  • Topoisomerases v.v.v.imp
  • Leading and Lagging strand imp
  • Exonuclease & Endonuclease imp
  • Fig 30.21, 30.23, 30.24 v.v.imp

(EnR-B-022)

  • DNA repair is an important topic u must do it all
  • Pg 475 to 477
  • Xeroderma pigmentosum v.v.imp

(EnR-B-023 to 025)

  • No need to do structure of RNA as not a part of syllabus
  • Start chapter from (III-Prokaryotic…) pg no 484 to 493
  • Again whole chapter is important but most important things are listed below
  • Fig 31.10 imp
  • Post-transcriptional changes v.v.v.imp

(EnR-B-026 to 028)

  • No need to do genetic codon as not in syllabus
  • Must do Mutations as part of previous LOs
  • The topic (III-Components Required For Translation) is not in ur syllabus but u should read it to understand the chapter. Rest is up to u.
  • Wobble hypothesis v.v.v.imp (IV-Codon Recog….)
  • Do chapter from pg 502 to 510
  • Most important things listed below
  • Shine-Delgarno Sequence imp
  • Fig 32.13, 32.14 imp
  • Co & Post-translational modifications v.v.v.imp

(EnR-B-029)

  • We did whole chapter in our 2nd yr as college faculty taught us so. They also assessed
  • But whole chapter is not in ur syllabus but still its a very important chapter
  • Do this chapter from pg 515 to pg 519 then pg 524 & 525
  • Lac operon v.v.v.imp (Fig 33.4 ratti honi chahiye)
  • Tryptophan operon imp
  • Iron metabolism & RNA interference v.v.imp
  • Rest chapter is up to you

(EnR-B-030)

  • Don’t do complete chapter as not in syllabus
  • Do DNA Cloning pg 534 to 537 (Fig 34.6)
  • Do DNA Sequencing from pg 539 (Fig 34.9 only)
  • Do Southern Blotting complete topic on pg 540. It will also cover Northern & Western Blotting. Also do Fig 34.25 imp
  • Do RFLP from pg 541 to 547
  • Do PCR from pg 547 to 550 v.v.v.imp topic (Was asked in Proff Written n Viva both)
  • Do Human Genome Project from Satya chapter 28

Chromosomal Abnormalities

Pedigrees & Karyotypes

Nuclear Receptor Mediated Signalling Pathway

Mutations (Mosaicism & Robertsonian Translocation)

Mendelian Inheritance Patterns

Hormonal Contraception Compresseds

GPCR Signalling Pathways

Features of Signal Transduction, Types of Hormones & Types of Receptors

Enzyme Linked Signalling Pathways

Medico Guides 2nd Block Physiology Guidelines

Prepared by:

                     Hassan e Muhammad (G14)

Compiled by:

                     Hafiz Muhammad Umair Noor (G12)

  • Guyton and Hall Textbook of Medical Physiology 14th Edition (Chapter numbers are mentioned according to this edition)
  • Jaypee Essentials of Medical Physiology 6th Edition

MEMBRANE PHYSIOLOGY

MS-P-001:

  • Membrane potentials across selectively permeable membrane pg 63  (read for Basic concept + mcqs)

MS-P-002:

  • ⁠Normal distribution of Ca Cl Na and K across membrane from fig 4.1
  • Membrane potential vs Nerst potential
  • Nernst potential and it’s basis
  • Nernst equation (calculate the nernst potential  for Na and K by putting values in the equation)

MS-P-003:

  • Goldman Equation pg 64 imp(use to calculate diffusion potential & resting potential when membrane is permeable to several different ions)

MS-P-004:

  • Resting membrane potential of neurons pg 65
  • Table 5.1 (mcqs)
  • Fig 5.5
  • Origin of RMP (seq)  & physiological basis i.e factors contributing
  • ⁠Hyperkalemia and Hypokalemia( imp)  ( pic is shared in the group)
  • ⁠Membrane Stabilizers ( lidocaine, calcium, mexiletine, valproic acid)
  • ⁠Inhibition of excitability stabilizers and local anesthetics pg 76 ( v imp) and their mechanism of action

MS-P-007:

  • Neuron action potential pg 67 (definition+ all stages)
  • Fig 5.6 imp ( also do it from the pic shared in the group )
  • Voltage gated Na and K channels
  • Na channels can be blocked by tetrodotoxin when applied outside the cell membrane (mcq)
  • K channels can be blocked by tetraethylammonium ion when applied to interior of nerve fibre (mcq)
  • Initiation of action potential pg 71( read)
  • Propagation of action potential (read)
  • All or nothing principle pg 72 (imp)
  • Re establishing Na and K ionic gradients after action potential pg 72 (imp)
  • Properties of action potential (pic is shared in the group)
  • Monophasic action potential (pic is  shared in the group)
  • Refractory period ( pic is shared in the group) relative v/s absolute

MS-P-008:

  • Role of Other ions during action potential pg 70 blue box ( v imp + tetany is seq ) role of Ca+ in it
  • Rheobase , chronaxie , utilization time ( vimp pic is shared in the group)

MS-P-011:

  • Special characteristics of signal transmission in nerve trunks (imp) pg 74
  • saltatory conduction and its importance

MS-P-009(a):

  • Graded potential + table 31.1 basis& properties
  • Graded vs Action Potential difference
  • Compound Action Potential .. basis& properties

NERVE PHYSIOLOGY

MS-P-005(a):

  • Complete chapter till functionsof neurilemma
  • Neuron anatomy
  • Neuron classification
  • Myelin sheath, neurilemma

MS-P-005(b):

  • Complete chapter 
  • Neuroglial cells and their roles
  • Myelination process
  • Axonal transport ( pic is shared in the group)

MS-P-006:

  • Complete chapter
  • Nerve fibers classification  table 135.1

MS-P-009(b): Synapse

  • Fig 140.4
  • Fig 140.5

MS-P-010:

  • Functional classification of synapse
  • Fig 140.2 +140.3

MS-P-012:

  • Multiple Sclerosis
  • GB syndrome (google)
  • Causes, features and pathophysiology
  • Degeneration of neuron two types
  • Regeneration of neuron

MUSCLE PHYSIOLOGY

MS-P-013:

  • Physiological anatomy of skeltal muscle
  • Sarcomere
  • Fig 6.3
  • Jaypee Table 28.1 (Diference)

MS-P-014:

  • ⁠ Charcteristics of muscle contraction
  • Fig 6.12
  • Also do examples Of Isotonic and isometric contraction
  • Fast vs slow muscle fibres

MS-P-015:

  • Motor unit
  • Force summation
  • Multiple summation
  • Frequency summation and tetanization (imp)
  • Treppe
  • muscle fatigue
  • Remodeling +Blue box

MS-P-016:

  • Complete Chapter
  • Anatomy, generation and conduction of impulse at NMJ
  • Generation of endplate potential
  • Excitation and contractions coupling (imp)
  • Myasthenia Gravis (v.imp )
  • NMJ enhancer and inhibitors

MS-P-017:

  • Types of Smooth Muscle
  • Physiologivcal basis Of Smooth Muscle contraction
  • Smooth muscle contraction without Action Potential
  • Hormones causing contractions without Action Potential
  • Latch mechanism and importance
  • Stress Relaxation
  • Regulation By Calcium
  • Nervous and hormonal Control (Complete till end)

Medico Guides 2nd Block Histology Guidelines

Prepared by:

                     Mahnoor (G14)

Compiled by:

                     Hafiz Muhammad Umair Noor (G12)

  • If you do it in a right way, you can get all those easy marks.
  • Give priority to notes shared in the group and give a read to book for mcqs
  • Diagrams are very important, 1st year diagrams are quite easy. Every diagram is important (frequently asked in exams)
  • Histology’s trick is same as that of Gross anatomy (Visual memory), Visualize the Pictures and its features! Thats all they ask.
  • Medical Histology by Laiq Hussain Revised 7th Edition (Chapter numbers are mentioned according to this edition)
  • Difiore’s Atlas of Histology
  • Mannual Of Histology (your practical notebook!)
  • Shortlisted notes of histology are also shared in the group (By Zayn ul Hassan from G12)

(MS-A-075, MS-A-076)

  • Histo diagram of every type (vv imp)
  • Diff b/w 3 types from your practical copy with examples (asked in viva)
  • Microscopic features and function of perichondrium

(MS-A-072, MS-A-073, MS-A-074)

  • Organic and inorganic matrix for mcqs
  • Metabolic role of bone
  • Diff b/w types from your practical copy
  • Haversian system (v imp)
  • Compact and spongy bone diagram (vvv imp)
  • Ossification types and features
  • Zones of growth (mcqs)
  • Bone repair recall it from GA /NOTES
  • Clinicals (Osteoporosis, osteopenia, osteopetrosis, osteophytes)
  • Appositional growth and Interstitial growth(our proff qs)

(MS-A-070, MS-A-071)

  • Diff b/w muscle types from practical copy
  • Caveolae, dark, light, I and A band, sarcomere for mcqs
  • Triad and diad present in which type
  • Intercalated disc (imp proff qs)
  • Hyperplasia and hypertrophy of muscle fibres
  • Histopathology of Leiomyoma.

Medico Guides 2nd Block Embryology Guidelines

Prepared by:

                     Mahnoor (G14)

Compiled by:

                     Hafiz Muhammad Umair Noor (G12)

  • KLM Clinically Oriented Embryology 11th Edition
  • Langman Medical Emryology 14th Edition

Note:

  • Do all clinicals

MS-A-065:

  • Skip genetic and molecular factors
  • Straited skeletal muscle development make flow chart
  • Innervation Of Axial
  • Skeletal Muscles + fig 11.4
  • Origin of muscles from abaxial and primaxial precursor table 11.1 (vvvv imp)
  • SMCs and Cardiac development just read it
  • Clinicals
  • Poland sequence
  • Prune belly syndrome
  • Muscle dystrophy

MS-A-066:

  • Limb development and growth. Shortlist it & Make a flow chart
  • Topographic anatomy of UL and LL
  • Fig 12.5(imp)
  • All clinicals given in Langman (vvv imp)
  • Amelia
  • Meromelia
  • Phocomelia
  • Cleft Hand and Foot
  • Polydactyly
  • Brachydactyly
  • Syndactyly
  • Congenital club foot

MS-A-069:

  • Development of bone and cartilage only

MS-A-067:

  • Blood supply of limbs
  • Cutaneous innervation of limbs

Medico Guides 2nd Block Biochemistry Guidelines

Prepared by:

                     Ibtihal Iftikhar (G14)

                     Muhammad Abdul Rehman Wazir (G14)

Compiled by:

                     Hafiz Muhammad Umair Noor (G12)

  • Lippincott Illustrated Reviews: Biochemistry 8th Edition (Chapter numbers are mentioned according to this edition)
  • Satyanarayana Biochemistry 6th Edition
  • Harper’s illustrated Biochemistry 30th edition
  • ABC of Clinical Genetics 3rd edition
  • Chatterjea Textbook of Medical Biochemistry 8th edition
  • Instant Biochemistry by Faiq Ahmed 3rd edition

CARBOHYDRATES

MS-B-001:

  • Classification of carbohydrates:
  • General Classification pg # 9 & 10
  • Monosaccharide Classification pg # 11 (Table 2.1 & 2.2)
  • Oligosaccharide(disaccharide) Classification pg # 19 & 20
  • Polysaccharide Classification pg # 20 to 25
  • Biomedical importance of each class of carbs is given along with their classification

MS-B-002:

  • Isomerism of carbohydrates pg # 10 to 15

MS-B-003 (a):

  • Physical properties of carbohydrates
  • Chemical properties of carbohydrates (Reactions of monosaccharides) pg # 15 to 18
  • Difference between proteoglycans and glycoproteins is given in the pic shared below

MS-B-003 (b):

  • Structure, function & clinical significance of Glycosaminoglycans (GAGs) pg # 173 to 175 (till before synthesis only) (Fig 14.4 vvvv.imp)

MS-B-003 (d):

  • Transport & uptake of glucose, pg # 105 to 107 (heading IV. Glucose transport into cells)
  • Glycolysis reactions & regulation (heading V. Glycolysis reactions, heading VI. Hormonal regulation)

MS-B-004:

  • Full chapter in detail

PROTEINS

MS-B-003 (c):

  • Structure & function of Fibrous proteins pg # 45 to 50 (Collagen) & pg # 52 (Elastin)
  • Fig 4.7 is imp ( Rather than doing the whole text, you can do biosynthesis from this fig )
  • Diseases associated with Fibrous proteins pg # 50 to 53 (Ehler-Danlos syndrome, Osteogenesis Imperfecta, Alport syndrome & Emphysema)
  • Role of Vitamin C in collagen synthesis (Hydroxylation) pg # 49
  • Duchene Muscular Dystrophy from the PDF with you.

MS-B-005:

  • Digestion & absorption of proteins, pg # 271 to 276

MS-B-006:

  • Transamination from pg # 276 to 278
  • Oxidative Deamination from pg # 278 to 279
  • Do Deamidation, Decarboxylation & Transdeamination from PDF shared.

MS-B-007:

  • Role of PLP covered in Transamination reaction ( Fig 19.9 )
  • Role of Glutamate, Glutamine & Alanine (GLUCOSE-ALANINE CYCLE) pg # 279 (Topic : Ammonia transport to liver)
  • For ammonia transport to liver, 2 pathways are mentioned, do both+ Fig 19.13 (vvv imp)

MS-B-008:

  • Urea Cycle pg # 279 to 282

MS-B-009:

  • Hyperammonemia pg # 282 till end of chapter

MS-B-010:

  • Metabolism of Amino Acids pg # 290 to 298

MS-B-011:

  • Amino Acid Metabolism Disorders pg # 298 till end of chapter

VITAMINS

MS-B-003 (c):

  • Sources, functions, active form & deficiency of Vit C, pg 427 & 428
  • Role of PLP, pg # 428

Amino Acid Metabolism Reactions by Medico Guides